Avestin Inc. address this issue in numerous ways in their industry leading range.
It is a common misconception that a fixed geometry homogenising valve is critical to ensuring scalability of homogenisers. This is not true, and Avestin have shown this via their dynamic homogenising valve, which minimises blockage risk and allows for direct pressure regulation.
The valve geometry remains consistent and scalable throughout the range.
More impressively, each system boasts an incredibly small minimum processing volume respective to its flow rate of sample, allowing a high throughput system to be utilised for smaller scale if needed.
For example, the Avestin EmulsiFlex C160 processes samples at a rate of up to 160L/hr, whilst being suitable for volumes as small as 250 mL.
The C160 has an A version and a B version: The A version can operate at up to 20,000 psi homogenising pressure, whilst the B version operates at up to 30,000 psi. Pressure regulation can be manual or automated. The induced pressure does not impact the machine flow rate – again improving scalability of the process, as well as diagnostics.