Solvent evaporation is used for an incredibly wide range of applications with many different solutes, solvents and containers. Using the right sample holder for your container type is important to ensure operating efficiency and to prevent product waste.
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Inspiralis is a company based in Norwich which specialises in providing topoisomerases, ligases and other DNA-modifying proteins which are used in the drug-discovery process by the pharmaceutical industry and academia. Topoisomerases are proteins which alter the topology of DNA, preventing it bec...Read more
Controlling the pressure
Another crucial parameter to consider when drying water /ACN HPLC fractions using a centrifugal evaporator is pressure control.
[caption id="attachment_3514" align="alignleft" width="300"] Figure 3: Boiling point of water/ACN mixes at different pressures[/caption...Read more
Even though mixtures of water/ACN alone may not bump, the addition of actual compounds sometimes changes this. Bumping is preventable by employing a controlled vacuum ramp to the centrifugal evaporator when initially pumping down, and increasing the centrifugal force to greater than 450G....Read more