Viewing posts categorised under: Application and Tech Notes

Sample Holders: The Right Tool for the Job

by in Application and Tech Notes, BPS News

Solvent evaporation is used for an incredibly wide range of applications with many different solutes, solvents and containers. Using the right sample holder for your container type is important to ensure operating efficiency and to prevent product waste. Thermal conductivity [caption id="attachme...Read more

Application Note: High Pressure Homogenisation and Protein Expression

by in Application and Tech Notes

Inspiralis is a company based in Norwich which specialises in providing topoisomerases, ligases and other DNA-modifying proteins which are used in the drug-discovery process by the pharmaceutical industry and academia. Topoisomerases are proteins which alter the topology of DNA, preventing it bec...Read more

Controlling Crystal Polymorphism

by in Application and Tech Notes, BPS News, BPS Right Sidebar Content

Polymorphism can potentially be found in any crystalline material. It is particularly important in the development of pharmaceutical ingredients as different crystal form can have significantly different physical, chemical and biological properties and many drugs receive regulatory approval for o...Read more

Optimal Drying of HPLC fractions

by in Application and Tech Notes, BPS News

Part 3 Controlling the pressure Another crucial parameter to consider when drying water /ACN HPLC fractions using a centrifugal evaporator is pressure control. [caption id="attachment_3514" align="alignleft" width="300"] Figure 3: Boiling point of water/ACN mixes at different pressures[/caption...Read more

Optimal Drying of HPLC Fractions

by in Application and Tech Notes, BPS News

Part 2 Even though mixtures of water/ACN alone may not bump, the addition of actual compounds sometimes changes this. Bumping is preventable by employing a controlled vacuum ramp to the centrifugal evaporator when initially pumping down, and increasing the centrifugal force to greater than 450G....Read more

Common Misconceptions in Freeze Drying – Part 2

by biopharma-admin in Application and Tech Notes, BPS News, BPS Right Sidebar Content

May 2013 Freeze drying (lyophilisation) is a stabilisation method that is widely used in the pharmaceutical industry for drugs, vaccines, antibodies and other biological material. Freeze drying can be a complex process to manage effectively but despite improvements in analytical and process sc...Read more

Common Misconceptions in Freeze Drying: Part 1

by biopharma-admin in Application and Tech Notes, BPS News, BPS News Cat 1, BPS Right Sidebar Content

March 2012 Freeze drying can be a complex process to handle effectively but despite improvements in analytical and process science a number of misconceptions persist. Below we look at a selection of those we encounter most often. 1.  Colder condenser temperatures mean faster freeze drying It...Read more