Viewing posts categorised under: Application Notes

Tech Note from SP Scientific: Drug Discovery Workflow for PROTAC with a Focus on Eliminating Bottlenecks in Evaporation

by biopharmaelena in Application Notes

An emerging modality of therapeutics called PROteolysis TArgeting Chimeras (PROTACs) could enable the design of new drugs targeting “undruggable” proteins, this development has led to great interest in the pharmaceutical and biotechnology industries. However, synthesis of PROTACs requires numerou...Read more

Optimised Marine Natural Products Discovery and Screening: Search for Novel “Superbug” Antiobiotics

by in Application Notes

Could the search for novel antibiotics from marine organisms be the next best approach? Contrary to popular belief, the past two decades have seen an increase in the use of marine natural products in the field of drug discovery. In this study, drug like molecule mixtures were fractioned using Se...Read more

New Preparative SFC System for Applications in Chiral Compound Purification

by in Application Notes

Have you considered the Prep SFC100 for your chromatography needs yet? Demonstrating three studies in which Sepiatec's compact Prep SFC100 system can be used, this application note exploits the versatility of the system. It's capability to handle a range of preparative separations combined with ...Read more

Impact on Modifier Selection on Enantioselectivity in SFC

by in Application Notes

A Study on the Selection of Modifiers and their impact on Enantioselectivity in Chiral Stationary Phases (CSPs) When trying to find an analytical SFC method that can resolve two specific isomers, this process often involves screening different column and mobile phase combinations. To increase ef...Read more

Application Note from Genevac – Extracts of Gymnema sylvestre Inhibit the Sodium‐Dependent Glucose Transporter 1

by biopharmacharis in Application Notes

Extracts of the Chinese Herbal Remedy Gymnema sylvestre Inhibit the Sodium‐Dependent Glucose Transporter 1 By Yu Wang, Corinna Dawid, Gabor Kottra, Stephen Pickrahn, Hannelore Daniel and Thomas Hofmann, Technische Universität München; Alison Wake, Genevac Ltd. Introduction Hyperglycemia ...Read more

Avestin Emulsiflex: Supporting the frontiers of Cancer research

by in Application Notes, Biopharma Process Systems

  Case Study Avestin Emulsiflex: Supporting the frontiers of Cancer research Use of Avestin Liposome Extrusion.   Background Bacteria can cause many different types of infections as they have many virulence factors for example adherence proteins, capsules, biofilm formation, endotoxi...Read more

Vapour Pressure of Ice

by in Application Notes

The driving force behind freeze drying is the pressure differential between the product chamber and the condenser: the greater the difference, the faster the flow of vapour away from the drying product. The condenser must be significantly colder than the product for effective freeze drying. The t...Read more

Sample Holders: The Right Tool for the Job

by in Application Notes, BPS News

Solvent evaporation is used for an incredibly wide range of applications with many different solutes, solvents and containers. Using the right sample holder for your container type is important to ensure operating efficiency and to prevent product waste. Thermal conductivity [caption id="attachme...Read more

Application Note: High Pressure Homogenisation and Protein Expression

by in Application Notes

Inspiralis is a company based in Norwich which specialises in providing topoisomerases, ligases and other DNA-modifying proteins which are used in the drug-discovery process by the pharmaceutical industry and academia. Topoisomerases are proteins which alter the topology of DNA, preventing it bec...Read more

Controlling Crystal Polymorphism

by in Application Notes, BPS News, BPS Right Sidebar Content

Polymorphism can potentially be found in any crystalline material. It is particularly important in the development of pharmaceutical ingredients as different crystal form can have significantly different physical, chemical and biological properties and many drugs receive regulatory approval for o...Read more