Could the search for novel antibiotics from marine organisms be the next best approach?
Contrary to popular belief, the past two decades have seen an increase in the use of marine natural products in the field of drug discovery. In this study, drug like molecule mixtures were fractioned using Se...Read more
Have you considered the Prep SFC100 for your chromatography needs yet?
Demonstrating three studies in which Sepiatec's compact Prep SFC100 system can be used, this application note exploits the versatility of the system. It's capability to handle a range of preparative separations combined with ...Read more
A Study on the Selection of Modifiers and their impact on Enantioselectivity in Chiral Stationary Phases (CSPs)
When trying to find an analytical SFC method that can resolve two specific isomers, this process often involves screening different column and mobile phase combinations. To increase ef...Read more
by biopharmacharis in Application Notes
Extracts of the Chinese Herbal Remedy Gymnema sylvestre Inhibit the Sodium‐Dependent Glucose Transporter 1
By Yu Wang, Corinna Dawid, Gabor Kottra, Stephen Pickrahn, Hannelore Daniel and Thomas Hofmann, Technische Universität München; Alison Wake, Genevac Ltd.
Hyperglycemia ...Read more
Avestin Emulsiflex: Supporting the frontiers of Cancer research
Use of Avestin Liposome Extrusion.
Bacteria can cause many different types of infections as they have many virulence factors for example adherence proteins, capsules, biofilm formation, endotoxi...Read more
Solvent evaporation is used for an incredibly wide range of applications with many different solutes, solvents and containers. Using the right sample holder for your container type is important to ensure operating efficiency and to prevent product waste.
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Inspiralis is a company based in Norwich which specialises in providing topoisomerases, ligases and other DNA-modifying proteins which are used in the drug-discovery process by the pharmaceutical industry and academia. Topoisomerases are proteins which alter the topology of DNA, preventing it bec...Read more
Controlling the pressure
Another crucial parameter to consider when drying water /ACN HPLC fractions using a centrifugal evaporator is pressure control.
[caption id="attachment_3514" align="alignleft" width="300"] Figure 3: Boiling point of water/ACN mixes at different pressures[/caption...Read more