High Pressure Homogenisation

Avestin Inc. boast industry leading homogenisation and extrusion technologies, associated with superior results and a robust, user-friendly manner of operation.

These versatile systems are applied across numerous industries, for applications including:

Cell Disruption/Lysis
Liposomes
Nanoemulsions
Particle Size Reduction
Nanoparticles

With its unique, dynamic homogenising valve design, from the benchtop (1-5L/hr) to production (500/1000L/hr) scale, comes a smooth homogenisation process with reliability.

Standard operation between 500 – 30,000 psi homogenising pressure; manual or automated.

GMP suitable, the range has 21 CFR Part 11 compliant systems available if required, and an array of documentation/certification options including FAT, SAT, IQ/OQ, surface roughness testing, material traceability and more.

Its success in industry is reflected by the excess of 2000 installations worldwide.

List of EmulsiFlex users

High Pressure Homogeniser Systems

With world-leading scalability, and a versatility in suitable processing volumes, Avestin can be your perfect homogenisation partner, from R&D/benchtop through to scale up operations up to 1000L/hr:

Below are some of the systems available, though please feel free to contact bps@biopharma.co.uk to hear more, and to find out which would be the best system for you.

C3

3L/hr Flow Rate

10mL min. sample vol

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C5

1-5L/hr Flow Rate

10mL min. sample vol

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D20

20L/hr Flow Rate

25mL min. sample vol

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C50

15-50L/hr Flow Rate

50mL min. sample vol

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C55

55L/hr Flow Rate

100mL min. sample vol

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C160

160L/hr Flow Rate

250mL min. sample vol

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Biopharma is pleased to exclusively supply products from Avestin Inc. throughout the UK & Ireland.

Latest Additions to the Avestin Inc. Range

The new Automatic Homogenising Pressure Control accessory allows the user to input the desired homogenising pressure onto a touchscreen HMI.

The homogeniser would then ramp up to and maintain that pressure, autonomously.

Advantages include:

Improved accuracy in pressure identification via digital display and line graph
Mirrors GMP-type processing
Reduced homogenising pressure variability
More alignment with larger scale processing, to assist with scale-up/scale-down
Retrofittable onto existing benchtop units.

Integrated into the machine cabinets of new D20 and larger systems. For existing units and new C3 and C5 units, it exists as a standalone unit.

The Filter/Extruder Accessory for Avestin Homogenisers offers a scale up to the Avestin LiposoFast Series (see below) of liposome extruders.

Diameters available: 47 mm, 90 mm, 142 mm
Pressure: up to 8,000 psi (550 bar), depending on specifications

The combination of homogenisation and extrusion often reduces the required number of passes to achieve the desired particle size and size distribution.