Articles & Resources

March 2, 2023

Improve your solvent evaporation process in small molecule drug development with EXALT

Traditionally, small molecule drugs dominated the treatment of human diseases, due to their adaptable nature, size, and typical physiochemical properties. All of which help support highly effective enzyme inhibitor and allosteric modifier,
February 28, 2023

Miniaturization of Freeze Drying: Process Optimization in the LyoCapsule Using Innovative PAT- SP Scientific Webinar Tech Note

Recently, Dr Alexandra Braun Ph.D., GILYOS GmbH, presented a webinar describing data on the benefits of using a miniaturized lyophilizer (LyoCapsule™, SP Scientific) that can freeze-dry as little as seven vials at a time for early stage cycle optimization.
February 28, 2023

Webinar Tech Note from SP Scientific: Equipment capability of freeze-dryers and its relevance to the graphical design space for primary drying

In September, Dr. Jayasree M. Srinivasan from Baxter BioPharma Solutions presented a webinar discussing how to measure and compare equipment capabilities of lab-scale and production-scale freeze dryers to define optimal design space parameters.
February 28, 2023

Webinar Technote from SP Scientific: Freeze Drying of Vaccines – Challenges and Concepts in Formulation and Process Development.

Recently, Ms. Julia Kosan, a PhD candidate from Friedrich Alexander University, Erlangen, Germany presented a webinar that discussed the suitability of freeze-drying vaccines to increase their thermostability.
February 28, 2023

Tech Note from SP Scientific: Drug Discovery Workflow for PROTAC with a Focus on Eliminating Bottlenecks in Evaporation

An emerging modality of therapeutics called PROteolysis TArgeting Chimeras (PROTACs) could enable the design of new drugs targeting “undruggable” proteins, this development has led to great interest in the pharmaceutical and biotechnology industries. However, synthesis of PROTACs requires numerous evaporation steps, causing bottlenecks in their production and slowing the drug development process.