Fillers and Stoppering

LI Linear Fillers

BI Rotary Fillers

SY Syringe Fillers

LI Linear Fillers

Linear filling, stoppering/tip placement/pump inserting and crimping or closing machine for bottles and vials up to 12,000 u/h. This system is compatible with RABs or isolator enclosures. The system is able to work with stainless steel or ceramic rotary piston pumps or peristaltic pumps. Systems are available for manual or semi-automatic debagging, manual, semi-automatic or automatic delidding for pre-sterilized glass as well as cleanroom unscrambler’s for ophthalmic containers. Systems are 21 CFR Part 11 and audit trail compatible.

These units can be integrated with a vial washer, depyrogenation tunnel, freeze dryer and freeze dryer loading systems, cappers, external vial washers and tray loaders to provide an integrated full line solution.

 

BI In-Line Filler & Stoppering Systems

In-line filling and stoppering systems, such as the LyoStar® BI I/LFiller, offer a versatile fill-finish solution for modern R&D and production environment.

Designed by the experts at SP i-Dositecno as an all-in-one compact machine that allows for the provision of a complete filling, stoppering and capping system that is ideally suited to small-scale filling operations. The adaptable and modular configuration, offers the flexibility of quick and easy set-up for changeovers to accommodate different containers and batch sizes, which is especially desirable in CMO environments

Features :

Key features and benefits of the BI I/L fill-finish systems include:

  • A robust, compact footprint
  • built to meet cGMP and GAMP 5 compliance
  • can process 2 to 100 ml containers with star-wheel change part for different container sizes
  • designed for liquid, powder, or tablets
  • vibratory stopper bowl for serum or lyo stoppers
  • option for integration with washer and tunnel or infeed for ready-to-use components
  • servo driven movement for filling operation
  • can be integrated with RABS or isolator or a standalone equipment
  • equipped with peristaltic or piston pump for easy set up

BI Rotary Filler & Stoppering Systems

Rotary filling, stoppering/tip placement/pump inserting and crimping or closing machine for bottles and vials up to 6000 u/h. The system is compatible with RABs or isolator enclosures. The system is able to work with stainless steel or ceramic rotary piston pumps or peristaltic pumps. Systems are available for manual or semi-automatic debagging, manual, semi-automatic or automatic delidding for pre-sterilized glass as well as cleanroom unscrambler’s for ophthalmic containers. Systems are 21 CFR Part 11 and audit trail compatible.

These units can be integrated with a vial washer, depyrogenation tunnel, freeze dryer and freeze dryer loading systems, cappers, external vial washers and tray loaders to provide a full line integrated solution.

SY Syringe Fillers

Robot filling and plungering machine for glass and plastic syringes, cartridges and vials in nest up to 6,000 u/h with two nozzles, 12,000 u/h with five nozzles and 24,000 u/h with 10 nozzles. The syringe filler is compatible with RABs or isolator enclosures. The system is able to work with stainless steel or ceramic rotary piston pumps or peristaltic pumps with possible standard filling with mechanical plunger introduction or vacuum plunger introduction. Automatic nest unloading and loading of tubes. The cleanroom-style robot is used to position syringes for filling and stoppering. Manual or semi-automatic debagging and manual, semi-automatic or automatic de-lidding are available along with 21 CFR Part 11 and audit trail capabilities.

Machines are also available for de-nesting, plunger insertion and labelling of syringes and cartridges.