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Freeze-drying (lyophilisation) is a common method of stabilization for protein-based therapeutics and vaccines. While lyophilisation is considered more gentle than other drying methods, proteins are often formulated with amorphous saccharides or polymers, which can serve not only to prevent denaturation during processing but also as a rigid matrix that provides some physical stabilization in the dried state.
This application note describes a study measuring the effect of Glycerol on the Mechanical Properties of Model Biotherapeutic Formulations. The study analysed the influence of several excipients in varying proportions on the mechanical properties of freeze-dried formulations of two model proteins, investigated by MicroPress.
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