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Application note: Lyotherm 3 – Optimisation of Lyophilisation Process Development in the Biopharmaceutical Industry

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Optimisation of the lyophilisation process starts with a deep understanding of the Active Product Ingredient (API) being used and its interaction with excipients. Knowledge of phase transitions occurring in the frozen state directly leads to efficiency and promotes stability during and after the lyophilisation process. One of the most powerful methods used to find these phase transitions is Zsinϕ analysis, performed using the Lyotherm3.

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