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Misconceptions in Freeze Drying

by biopharma-admin in Uncategorized

<<8: Shelf Spacing Requirements 9. Vacuum pumps are all the same “I have a vacuum in the lab that works fine, I’ll use that one” “I'll just connect the dryer to our house vacuum system” Many pumps often found in the lab – central vacuum systems, single stage pumps or diaphragm pumps – are...Read more

Misconceptions in Freeze Drying

by biopharma-admin in Uncategorized

<<6: Lower chamber pressure means faster freeze drying 7. Condenser overloads “Why does the condenser overload or by-pass when we’re processing far less than its stated overall capacity?” If vapour is being created at a rate faster than the condenser can trap it, the vapour will bypass the...Read more

Misconceptions in Freeze Drying

by biopharma-admin in Uncategorized

<<4: It doesn’t matter how a product is frozen—it’s the drying that’s important 5. Drier (lower final moisture content) is always better Freeze drying aims to increase the stability of a product by reducing the moisture levels, so it is easy to assume that the drier the product, the better....Read more

Misconceptions in Freeze Drying

by biopharma-admin in Uncategorized

<<2: "One size fits all" cycle development 3. Vials can be filled to any depth Product freeze-dries from the top (surface) down, and as it does a layer of dried product gradually builds up on top of the remaining frozen product. This dried layer creates an increasing impediment to the subli...Read more

Misconceptions in Freeze Drying

by biopharma-admin in BTL News Cat 1

Freeze drying can be a complex process to handle effectively but despite improvements in analytical and process science a number of misconceptions persist that prevent practitioners from achieving the best results. In this article we look at some of the misunderstandings we encounter most often. ...Read more

Freeze drying of PCR products

by biopharma-admin in BTL News, BTL Right Sidebar Content

August 2014 PCR is a common and often indispensable technique used in medical and biological research labs for applications including functional analysis of genes, the diagnosis of hereditary diseases and the detection and diagnosis of infectious diseases. Storage of PCR Materials by Freeze Dryi...Read more

Freeze Drying Simplified: Video

by biopharma-admin in BTL News, BTL Right Sidebar Content

July 2014 Linkam Scientific have created a short video to explain freeze drying and how freeze drying microscopy (Lyostat analysis) can help. Watch the video (opens a new window)>> More about Lyostat>>Read more

Vial Washers for the Compounding Pharmacy: Ensuring Preparation Safety

by biopharma-admin in Uncategorized

July 2014 The cleanliness of vials used to contain customized medications is of utmost concern to compounders. Many of today's compounding pharmacists use manual washing or a mechanical dishwasher to clean vials - even those that will be used to contain sterile injectables - but those methods a...Read more

Optimal Drying of HPLC fractions

by biopharma-admin in Uncategorized

Part 3 Controlling the pressure Another crucial parameter to consider when drying water /ACN HPLC fractions using a centrifugal evaporator is pressure control. [caption id="attachment_3514" align="alignleft" width="300"] Figure 3: Boiling point of water/ACN mixes at different pressures[/caption...Read more

Optimal Drying of HPLC fractions

by biopharma-admin in Uncategorized

July 2014 In pharmaceutical and chemical synthesis laboratories, high performance liquid chromatography (HPLC) is probably the most frequently used analytical separation technique. A widespread and growing application for HPLC is for product purification following chemical synthesis. Common HPL...Read more