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Viewing posts categorised under: Intelligent Freeze Drying

A 2020 Hindsight Look at How COVID-19 Has Affected the Freeze Drying Industry and What We Have Learned from It

by biopharmaelena in Application and Tech Notes, BPS News, BTL News, Intelligent Freeze Drying

2020 proved to be a challenging year in the field of freeze drying/lyophilisation due to the rapidly shifting timelines required to get products to market. This was especially prevalent across the diagnostic and pharmaceutical sectors. In this article, we will be considering why freeze drying is ...Read more

Scientific Poster: Quantification of the Physical Robustness of Lyophilized Biotherapeutics

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Download the full scientific poster: Read more

Application note: Lyotherm3 and Lyostat5 – Freeze Drying Fruit Juice for Easy Transport and Long-Term Storage

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Lyophilisation is a dehydration process which has been used throughout history as a means of preventing deterioration of perishable materials (the Incas stored potatoes at high altitudes where low pressures and temperatures dried them preventing them from spoiling) 1. First mentioned in literatur...Read more

Application note: How does Micro Collapse affect Lyophilised Cake Strength?

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

During freeze drying, products should be maintained below their critical temperatures, such as glass transition (Tg’), eutectic melt (Teu), and collapse (Tc), to ensure a safe and robust cycle and to reduce the risk of detrimental defects exhibited in the product post freeze drying. Defects can i...Read more

Application note: Identifying the Strength and Robustness of Lyophilised Beads

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Lyophilised beads are an innovative way to supply the avian population with an oral dose of drugs or vaccines, since the beads will easily blend in with dry feed. However, achieving precise control of dosage can be problematic if the beads were to break up in transport or handling, or when mixed ...Read more

Application note: Lyotherm 3 – Optimisation of Lyophilisation Process Development in the Biopharmaceutical Industry

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Optimisation of the lyophilisation process starts with a deep understanding of the Active Product Ingredient (API) being used and its interaction with excipients. Knowledge of phase transitions occurring in the frozen state directly leads to efficiency and promotes stability during and after the ...Read more

Application note: Process Analytical Technology employed in the Freeze Drying Process to determine the End of Primary drying and Cycle Optimisation

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Process Analytical Technologies (PAT) are analytical methods that can help to monitor a process in real time, enabling measurement of its effectiveness and assess how well the process achieves its end goal. They are employed in the manufacturing of various drug forms including solid dose, liquid ...Read more

Application note: MicroPress – How robust are your cakes?

by biopharmaszymon in App notes & Scientific posters, Application and Tech Notes, BPS Right Sidebar Content, Intelligent Freeze Drying

The use of freeze-drying (Lyophilisation) for labile drugs has been a staple in pharmaceutical world for over 40 years. However, this comes with several challenges, one of which is to produce strong and durable FD cakes that can withstand downstream processing after freeze drying and during trans...Read more

Application note (DSC): Analysis of formulations for freeze drying

by biopharmaszymon in App notes & Scientific posters, BTL News, BTL Right Sidebar Content, Intelligent Freeze Drying

Differential Scanning Calorimetry (DSC) is arguably the preferred method of thermal analysis for freeze drying. DSC measures the heat flow in and out of a sample over a temperature range compared against a reference pan which is usually empty. Traditionally heat flow is plotted against time but, ...Read more

How Biopharma Group is Solving The Freeze Drying Bottleneck For Diagnostic & Vaccine Production

by biopharmacharis in BTL News, BTL Right Sidebar Content, Intelligent Freeze Drying

[vc_row][vc_column][vc_column_text] As featured in the September 2020 issue of International Labmate (Pages 48-49), please see our latest article authored by Tim Lewis on how Biopharma Group has successfully adapted the freeze drying cycle development process for the production of diagnostic a...Read more