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Viewing posts categorised under: Intelligent Freeze Drying

Application note: Lyotherm 3 – Optimisation of Lyophilisation Process Development in the Biopharmaceutical Industry

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Optimisation of the lyophilisation process starts with a deep understanding of the Active Product Ingredient (API) being used and its interaction with excipients. Knowledge of phase transitions occurring in the frozen state directly leads to efficiency and promotes stability during and after the ...Read more

Application note: Process Analytical Technology employed in the Freeze Drying Process to determine the End of Primary drying and Cycle Optimisation

by biopharmaszymon in App notes & Scientific posters, BTL Right Sidebar Content, Intelligent Freeze Drying

Process Analytical Technologies (PAT) are analytical methods that can help to monitor a process in real time, enabling measurement of its effectiveness and assess how well the process achieves its end goal. They are employed in the manufacturing of various drug forms including solid dose, liquid ...Read more

Application note: MicroPress – How robust are your cakes?

by biopharmaszymon in App notes & Scientific posters, Application and Tech Notes, BPS Right Sidebar Content, Intelligent Freeze Drying

The use of freeze-drying (Lyophilisation) for labile drugs has been a staple in pharmaceutical world for over 40 years. However, this comes with several challenges, one of which is to produce strong and durable FD cakes that can withstand downstream processing after freeze drying and during trans...Read more

Application note (DSC): Analysis of formulations for freeze drying

by biopharmaszymon in App notes & Scientific posters, BTL News, BTL Right Sidebar Content, Intelligent Freeze Drying

Differential Scanning Calorimetry (DSC) is arguably the preferred method of thermal analysis for freeze drying. DSC measures the heat flow in and out of a sample over a temperature range compared against a reference pan which is usually empty. Traditionally heat flow is plotted against time but, ...Read more

How Biopharma Group is Solving The Freeze Drying Bottleneck For Diagnostic & Vaccine Production

by biopharmacharis in BTL News, BTL Right Sidebar Content, Intelligent Freeze Drying

[vc_row][vc_column][vc_column_text] As featured in the September 2020 issue of International Labmate (Pages 48-49), please see our latest article authored by Tim Lewis on how Biopharma Group has successfully adapted the freeze drying cycle development process for the production of diagnostic a...Read more

How increased remote working is boosting the popularity of specialised remote learning.

by biopharmacharis in BTL News, BTL News Cat 1, BTL Right Sidebar Content, Intelligent Freeze Drying

[vc_row][vc_column][vc_column_text] With the Covid 19 pandemic causing concerns about spreading infection and highlighting remote working practices throughout organisations large and small as a consequence, some people have, understandably, worried about whether to attend 'in person' training co...Read more

Application Note: Investigating the Effect of Glycerol on the Mechanical Properties of Model Biotherapeutic Formulations

by biopharmaelena in App notes & Scientific posters, BTL News, BTL Right Sidebar Content, Intelligent Freeze Drying

Freeze-drying (lyophilisation) is a common method of stabilization for protein-based therapeutics and vaccines.  While lyophilisation is considered more gentle than other drying methods, proteins are often formulated with amorphous saccharides or polymers, which can serve not only to prevent dena...Read more

Superior results and efficiencies achieved in food freeze drying

by gstrongitharm in BTL News, BTL Right Sidebar Content, Intelligent Freeze Drying, Uncategorized

Water is generally the main ‘ingredient’ in food and has a considerable impact on both physico-chemical and mechanical properties, which constantly change during storage [2,5]. The products shelf life is limited by the biological activity of microorganisms and water deeply affects it. Bacteria an...Read more

The End of an Era – Changes Are Afoot at Biopharma Group

by biopharmacharis in BTL News, BTL Right Sidebar Content

  It is with regret that we find ourselves announcing that, after 17 years of stellar service at the heart of Biopharma Group helping build the company to where it is today, Peter Williams has chosen to retire for personal reasons. Peter shall be stepping down from his role as Group Sal...Read more

How to prevent your cake from collapsing in Freeze Dried Products?

by biopharmaszymon in BTL News, BTL Right Sidebar Content, Uncategorized

Many drugs are unstable in solution and degrade rapidly over time, therefore they must be freeze dried to produce a suitable stable product which can be shipped and has an acceptable shelf-life for storage. The freeze dried product can be reconstituted to produce a solution containing the drug re...Read more