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Differential Scanning Calorimetry (DSC) 

DSC has historically been a ‘go-to’ analytical product for many pharmaceutical labs due to the versatility of the resulting data. During DSC analysis, the sample temperature is raised at a constant rate by heat input. The heat flow required to maintain this constant rate is then logged against temperature to generate the DSC trace, which as a result, shows exothermic and endothermic events.

Some of the most critical events in pharmaceutical freeze drying analysis are glass transitions, both dry state (Tg) and frozen state (Tg’). These apply to amorphous sample components, and are thermodynamically reversible changes that result in a shift in the specific heat capacity of the sample. These indicate a reorientation between amorphous and crystalline regimes and are often highly influential on a number of characteristics of the sample structure. The glass transitions are also visible as a change in the gradient of the DSC trace.

DSC Stage – Modular Add-On

The DSC stage modular add-on offers a new compact alternative for conducting thermal analysis on both liquid and dry state samples, especially since the DSC stage shares the same control module and peripherals with our Lyostat5 Freeze Drying Microscope where it can be purchased as an optional add-on expanding the Lyostat5 capabilities. Furthermore, the dual pan system allows for comparison against a reference sample and maximises the thermal signal from solute-related events over the ‘noise’ resulting from the solvent and pan.

Optical Analysis

One of the most important benefits of the DSC stage is that, unlike other DSC systems, it includes the ability to be mounted on an imaging station for visual degradation analysis and TASC (Thermal Analysis by Surface Characterisation) during DSC experiments through a sapphire window. Visually observing the physical changes that the DSC trace is quantitatively reporting can be of great benefit, especially for troubleshooting. These images can be made into videos and easily, exported with a data ribbon and annotated.

Technical Specification

  • Accurate control in a range -180°C to +450°C
  • Atmospheric purging (nitrogen or other) through gas inlets
  • Adjustable heating and cooling rate from 0.1°C min-1 to 30° C min-1
  • Heat flow accuracy 0.01 mW
  • Optical imaging with FLIR camera:
    • 1920×1200 resolution
    • 3 megapixel
    • 30 frames per second

DSC Analysis

We also offer a DSC analysis services performed by our experienced scientists, read more about this specialist analysis service here, where you will also be able to discover more about our DVS service too.

 

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